5-Methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine (2 mg)

Precursor 2 for [18F]FMAU
Product No.: MAU-95-0002

5-Methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine
Product No.:MAU-95
CAS No.:7288-28-0


   
Product Name: 5-Methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine
Synonyms: Pyrimidine, 5-methyl-2,4-bis[(trimethylsilyl)oxy]-; 2,4-Bis(trimethylsiloxy)-5-methylpyrimidine; 2,4-Bis(trimethylsilyl)-5-methyluracil; 2,4-Bis-O-(trimethylsilyl)thymine
CAS No.: 7288-28-0
Molecular Formula: C11H22N2O2Si2
Molecular Weight: 270.48
Application: Precursor 2 for [18F]FMAU
Presentation: Very sensitive to moisture; packed in dark glass crimp cap vials under argon atmosphere

Storage and Stability

  • Stored under argon in a desiccators; appears to be stable for months.
  • Short-term storage at higher temperatures does not affect product quality.

Notes

  • Complete documentation - Certificates of Analysis including testing reports of 1H-NMR and GC spectra for each shipment.
  • Customized dispensing available

Research

  • Mangner T.J. et al. Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU, [18F]FIAU, as potential PET agents for imaging cellular proliferation. Nucl. Med. Biol. 2003,30, 215-224.
  • Buursma A.R. et al. 18F-FEAU as a radiotracer for herpes simplex virus thymidine kinase gene expression: invitro comparison with other PET tracers. Nucl. Med. Commun. 2006, 27, 25-30.
  • Alauddin M.M. et al. Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model. Mol. Imaging 2004, 3, 76-84.
  • Alauddin M.M. et al. Synthesis and evaluation of 2'-deoxy-2'-18F-fluoro-5-fluoro-1-beta-D-arabinofuranosyluracil as a potential PET imaging agent for suicide gene expression. J. Nucl. Med. 2004, 45, 2063-2069