Brain imaging changes in individuals with Down's may help advance Alzheimer's trials

Researchers have characterized three different brain imaging changes in individuals with Down syndrome, who are at very high risk for development of Alzheimer's disease, even before the onset of progressive memory and thinking problems. Their findings could help set the stage to evaluate promising treatments to slow down or prevent the onset of Alzheimer's symptoms in these individuals, according to a study published in Alzheimer's & Dementia.

The scientists at Banner Sun Health Research Institute (BSHRI) and Banner Alzheimer's Institute (BAI) have also identified the approximate age—about 35 to 40—at which Alzheimer's-associated brain imaging changes occur in the Down's population, which could help pinpoint when to initiate investigational treatments in those trials. Read more.