Preclinical PET imaging of EGFR levels: Pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake

Abstract

Background

Though overexpression of epidermal growth factor receptor (EGFR) in several forms of cancer is considered to be an important prognostic biomarker related to poor prognosis, clear correlations between biomarker assays and patient management have been difficult to establish. Here, we utilize a targeting directly followed by a non-targeting tracer-based positron emission tomography (PET) method to examine some of the aspects of determining specific EGFR binding in tumors. Read more.

Tags: Cancer PET Research Abstracts

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