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Poor Sleep Tied to Alzheimer-Related Pathology

Sleep health may be target for early intervention

Self-reported poor sleep was associated with a greater presence of several cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease, according to a cross-sectional study.

Disrupted sleep or lack of sleep has previously been linked to a greater risk for brain amyloid plaque on PET imaging, but the study is among the first to show an association between poor sleep and amyloid and other biological markers for Alzheimer’s disease in the spinal fluid, wrote Barbara Bendlin, PhD, of the University of Wisconsin-Madison, and colleagues. Read more.

Comparative diagnostic accuracy of 18F-FDG PET/CT for breast cancer recurrence

Abstract

In the last decades, in addition to conventional imaging techniques and magnetic resonance imaging (MRI), 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) has been shown to be relevant in the detection and management of breast cancer recurrence in doubtful cases in selected groups of patients. While there are no conclusive data indicating that imaging tests, including FDG PET/CT, produce a survival benefit in asymptomatic patients, FDG PET/CT can be useful for identifying the site of relapse when traditional imaging methods are equivocal or conflicting and for identifying or confirming isolated loco-regional relapse or isolated metastatic lesions. Read more.

Automated fluorine radiolabelling moves closer to the clinic

New technique could improve tumour diagnosis and treatment

A new automated fluorine-18 labelling procedure could make this useful radioisotope easier to use in medical imaging. 

Positron emission tomography (PET) is a nuclear medicine technique that provides a non-invasive way to diagnose and design treatment for tumours. The technique monitors how positron-emitting radionuclides bound to biological targeting molecules accumulate in the body. The radionuclide accumulates in cancerous tissue, and its concentration provides both qualitative and quantitative information about the tumour. Read more.

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