Discrepancies in kappa opioid agonist binding revealed through PET imaging
Kappa opioid receptor (KOR) modulation has been pursued in many conceptual frameworks for the treatment of human pain, depression and anxiety. As such, several imaging tools have been developed to characterize the density of KORs in the human brain and its occupancy by exogenous drug-like compounds. Read more.
New PET imaging method may yield benefits over FDG for detecting certain cancers
German researchers have developed a PET imaging method that may raise the bar on diagnosing certain cancers. The method targets cancer-associated fibroblasts (CAFs), which have been linked to tumor growth and are present in over 90 percent of epithelial carcinomas such as pancreatic, colon and breast cancer. The team created a PET tracer based on a FAP-specific enzyme inhibitor (FAPI). Read more.
Coronary microvascular dysfunction tops BMI for CVD risk prediction
Coronary microvascular dysfunction (CMD) identified with cardiac stress PET testing was a better predictor of adverse events among obese patients than body mass index (BMI) and other traditional risk factors, researchers reported in the Journal of the American College of Cardiology.
Although BMI is easy to calculate and widely used in clinical practice, it is far from a perfect risk marker, the authors noted. Read more.
Researchers identify pitfall in popular prostate cancer PET imaging method
Awareness of the potential to misinterpret PSMA PET results can increase diagnostic accuracy and more accurately guide therapy
Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging has become a popular method for determining the stage of a patient's prostate cancer. However, researchers have identified a major pitfall in this imaging technique and are cautioning medical professionals to be aware of the potential for misdiagnosis when relying solely on PSMA PET. Read more.
Novel PET tracer detects small blood clots
Blood clots in veins and arteries can lead to heart attack, stroke, and pulmonary embolism, which are major causes of mortality. German researchers show that targeting GPIIb/IIIa receptors, the key receptor involved in platelet clumping, with a fluorine-18 (18F) labeled ligand is a promising approach for diagnostic imaging. Current imaging modalities rely on structural characteristics, such as vascular flow impairment, and do not address the critical molecular components. Read more.
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